Endocrine Abstracts

Background: The control of the Hypothalamic–Pituitary–Gonadal (HPG) axis is a highly complex process, with the hypothalamic arcuate-median eminence complex (Arc-ME) as the master regulating region. The transient activation of the HPG axis is essential for the development and function of the reproductive system. This project’s focus is the transient phase of HPG axis activation within the first weeks and months postpartum (minipuberty). The mechanisms guiding the...

Background: Klinefelter syndrome (KS) is the most frequent genetic cause of male infertility. Individuals share the endocrine hallmark of hypergonadotropic hypogonadism, displaying high gonadotropin levels due to deficient testicular function. A single-nucleotide polymorphism (SNP) located within the FSHB promoter region (−211G>T, rs10835638) was recently shown to be associated with reduced serum FSH levels and other reproductive parameters in men. The objec...

Background: Recently, a single nucleotide polymorphism (SNP) in the FSHB promoter (−211G>T, rs10835638) was found to be associated with lower serum FSH levels and oligozoospermia in males. In contrast, a SNP in the FSH-receptor gene (FSHR, 2039A>G, rs6166) was previously shown to be associated with FSH levels in women only.Subjects and methods: One thousand two hundred and thirteen male partners in infertile couples without known c...